As a matter of facts, M&S has been already applied to handle different issues pertaining to supply chain management such as optimization , policy analysis, and decision support [. Here, M&S has shown its effectiveness and its capability to take into account several factors and their mutual interdependencie along the chain from procurement to market. Anyway, the more the paradigm of lean supply chain is spreading, the more the actors involved and their mutual interrelations increase in number and therefore vulnerability and risk exposure grow.