Acetaminophen is the generic name of a drug found in many common brand-name over-the-counter
(OTC) products (e.g., Tylenol, Excedrin) and prescription (Rx) products (e.g., Vicodin and Percocet).
Acetaminophen is an important drug, and its effectiveness in relieving pain and fever is widely known.
Unlike other drugs commonly used to reduce pain and fever (e.g., nonsteroidal anti-inflammatory drugs
(NSAIDs), such as aspirin, ibuprofen, and naproxen), at recommended doses acetaminophen does not
cause stomach discomfort or bleeding. To date, the agency has considered acetaminophen safe when
used according to the directions on its OTC and Rx labeling. Taking more than the recommended dose
of 4 grams a day, however, can cause liver damage, ranging from abnormalities in blood tests used to
assess liver function to acute liver failure (ALF), and even death. Many cases of acetaminophen
overdose are caused by consumers inadvertently taking more than the recommended dose.