Apoptosis and PCD are not interchangeable terms (17). Cells can die by non-apoptotic forms of PCD, employing PCD mechanisms distinct from apoptosis (17,18). The structure of non-apoptotic PCD can be similar to the type II (autophagic) form of cell death (19). Cells undergoing autophagic death show extensive degradation of cytoplasmic organelles prior to nuclear destruction. There is no internucleosomal fragmentation of DNA during nonapoptotic PCD (17,18).