Abstract This quasi-experimental research study aimed to
investigate the effect of technological, pedagogical, and
content knowledge (TPACK)-based course design on mathematics,
science, and literacy education pre-service teachers’
TPACK. Participants in the study consisted of 31 mathematics,
32 science, and 38 literacy education pre-service teachers
who attended introduction to computers. To collect data, the
technological pedagogical content knowledge self-efficacy
instrument (TPACKSEI) developed by Graham et al. (2009)
was applied before and after the course. The results showed
significantimprovements in all groups of pre-service teachers’
mathematics, science, and literacy education self efficacy on
their TPACK.Moreover, therewere no significant differences
between natural science (mathematics and science education)
and social science (literacy) for pre-service teachers’TPACK.
However, there were significant differences between natural
science and social science pre-service teachers’ technological
knowledge and technological content knowledge.