The second method uses salt crystals of a defined-size.
Salt is poured into the silk solution,which induces gelation of the silk.
The salt is dissolved in water,leaving pores in the non-soluble silk scaffold.
Silk scaffolds can be easily modified in terms of their size, porosity,pore-size,mechanical strength and degradation time.
A few cancer models constructed based on silk matrics have been desribed,including hepatocarcinoma, osteosarcoma,squamous cell carcinoma and mammary adenocarcinoma models.