that 10 kDa is the
minimum MW required for inhibition; however, Zheng and Zhu
(2003) showed that a mixture of 0.25% (w/v) COS with MW
o5 kDa yielded the highest inhibition over E. coli, whereas a
305 kDa fraction had the highest effect against S. aureus, at a
similar concentration. Antibacterial activity over E. coli brought
about by oligomers (i.e. trimers to hexamers) was also reported
(Jeon and Kim, 2000)—even at 0.01% (w/v), while Ueno et al.
(1997) claimed that 2.2 kDa oligomers caused little effect on
microbial growth.