Long term use of antibiotics against acne is
outdated because of exacerbated antibiotic resistance
[6,7]. The development of antibiotic resistance is
multifactorial, including the specific nature of the
relationship of bacteria to antibiotics, how the
antibacterial is used, host characteristics, and
environmental factors. To overcome the problem of
A.Vijayalakshmi et al /Int.J. PharmTech Res.2011,3(1)