The University dates its foundation to the establishment of Osaka Technical College (大阪専門学校 Ōsaka semmon gakkō?) in 1925. Kinki University started in 1949 when the founder college merged with Osaka Science and Engineering University (大阪理工科大学 Ōsaka rikōka daigaku?), established in 1943. The first president was Koichi Seko.
Initially there were two schools: the School of Engineering and the School of Commerce (now the School of Business and Economics).
After the war, when food was in short supply, the university opened its Marine Research Center in 1948 in Shirahama-cho, Wakayama Prefecture. Today it is the Fisheries Laboratory. This was the first time that marine fish farming research was carried out in Japan. Other pioneering projects include, along with the opening of the Atomic Energy Research Institute, establishing the first private nuclear reactor facilities in 1960.
When Masataka Seko became the head of Kinki University in 1965, he built and improved the curricula and environment. In 1974, the School of Medicine was opened, followed by a teaching hospital one year later. Existing university buildings were reconstructed and laboratories and other facilities were improved and expanded. Another aspect of his vision that "Education comes from the environment" was realized: There is more greenery on campus.
In 1989, adding to a university that had concentrated on science and technology, the School of Literature, Arts and Cultural Studies was opened. At the same time, the School of Agriculture was moved to Nara Prefecture which was more conducive to studies concerned with the natural environment.
In 1993, the School of Biology-Oriented Science and Technology was opened in Uchita-cho, Wakayama Prefecture. It attracted public interest as the first center in Japan to concentrate on this new field concerning superior functions possessed by organisms.
As it comprises 11 schools, 44 departments, and a School of Medicine that runs three general hospitals, Kinki University covers many fields of research. The contribution it makes increase each year.