Therefore, inhibition of IL-6-induced STAT3 has been suggested to be a potential approach for the treatment of human immune and inflammatory diseases. In a preliminary bioassay, it was found that an n-BuOH-soluble fraction of G.pentapyllum possessed an inhibitory effect on IL-6-induced STAT3 promoter activity in Hep3B cells (IC50 value: 7.2 μg/