3. Results and discussion
3.1. Full factorial design
Screening designs, such as “full factorial design”, are used to
study the influence of each factor (X) on the response variables (Y)
and to indicate the most important factors (Dejagher and Vander
Heyden, 2011). The effect of each X and that of their interactions on
each Y is estimated by means of Pareto charts. These graphical
representations are useful to determine which factors and relevant
interactions have a significant effect, negative or positive, on each
response variable of the experimental design. Table 3 reports the
experimental results obtained for the 8 formulations (points 1–8).
It can be observed that mini-capsules prepared with the highest
concentrations of CS, PEC and HA (formulation 3) was characterized
by the smallest particle size, while the greatest value of
hydration parameter was shown by the formulation 5 prepared
with the highest PEC concentration and lowest CS and HA
concentrations. As for mechanical resistance, formulation 4,
characterized by the highest CS and PEC concentrations and by
the lowest HA concentration, presented the best performance. The
polymer concentrations employed for formulations 7 and 8 did not
produce mini-capsules.
3. Results and discussion3.1. Full factorial designScreening designs, such as “full factorial design”, are used tostudy the influence of each factor (X) on the response variables (Y)and to indicate the most important factors (Dejagher and VanderHeyden, 2011). The effect of each X and that of their interactions oneach Y is estimated by means of Pareto charts. These graphicalrepresentations are useful to determine which factors and relevantinteractions have a significant effect, negative or positive, on eachresponse variable of the experimental design. Table 3 reports theexperimental results obtained for the 8 formulations (points 1–8).It can be observed that mini-capsules prepared with the highestconcentrations of CS, PEC and HA (formulation 3) was characterizedby the smallest particle size, while the greatest value ofhydration parameter was shown by the formulation 5 preparedwith the highest PEC concentration and lowest CS and HAconcentrations. As for mechanical resistance, formulation 4,characterized by the highest CS and PEC concentrations and bythe lowest HA concentration, presented the best performance. Thepolymer concentrations employed for formulations 7 and 8 did notproduce mini-capsules.
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