The first report on the decisive role of vitamins in enhancing anaerobic biodegradation – in this case of chloroform (CF) – has been published by Guerrero-Barajas and Field [175]. They have noted that only negligible degradation of CF was observed in control cultures lacking redox active vitamins, but the addition of riboflavin (RF), cyanocobalamin (CNB12), and hydroxycobalamin enabled biodegradation of CF.