ABSTRACT
Stroke and depression have a strong bidirectional association: on the one hand, depression and
psychosocial distress are well known risk factors for stroke; on the other hand, stroke is known to be a
strong risk factor for depression. In the first 2 years after a stroke approximately one-third of patients
suffer from a post-stroke depression (PSD). PSD aggravates the burden of physical, psychological, and
social disability after stroke, and hinders patient participation in rehabilitation. PSD is associated with a
poorer outcome and increased mortality. For the treatment of PSD, selective serotonin reuptake inhibitors
(SSRIs) were recommended. Interestingly, SSRIs also have positive effects on motor recovery in stroke
patients even without depression, but may increase vascular risk.
ABSTRACTStroke and depression have a strong bidirectional association: on the one hand, depression andpsychosocial distress are well known risk factors for stroke; on the other hand, stroke is known to be astrong risk factor for depression. In the first 2 years after a stroke approximately one-third of patientssuffer from a post-stroke depression (PSD). PSD aggravates the burden of physical, psychological, andsocial disability after stroke, and hinders patient participation in rehabilitation. PSD is associated with apoorer outcome and increased mortality. For the treatment of PSD, selective serotonin reuptake inhibitors(SSRIs) were recommended. Interestingly, SSRIs also have positive effects on motor recovery in strokepatients even without depression, but may increase vascular risk.
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