are accompanied by a higher incidence of weight gain
and metabolic syndrome that may result in being
noncompliant with medications.[9,10] The prevalence of
metabolic syndrome in schizophrenic patients ranging
from 11% to 69% based on the medication that was
used by the patient.[11] The prevalence of metabolic
syndrome among Iranian patients with schizophrenia is
27.4%, 37.6%, and 38.7% that were reported in different
studies.[12] Atypical antipsychotics also showed an
increase in blood glucose and cholesterol levels and
the rise is specifically significant for clozapine.[13] The
prevalence of metabolic syndrome among patients who
are taking clozapine is ranging from 46% to 62%.[11]
The clozapine has also the highest rate of weight gain
among antipsychotics.[14] Clozapine is metabolized by
liver enzymes and has a half-life of 9.1-17.4 h.[15] The
weight gain is most likely due to the effect of clozapine
on H-1 receptor in hypothalamus.[16] If more serious
side effects, including: Agranulocytosis, myocarditis,
cardiomyopathy, and a prolonged QTc interval occurs,
discontinuation of medication may be warranted,[17] but