ACE inhibitor [3–7] and ARB [8–10] are also well
known to prevent the progression of diabetic nephropathy
[3–10]. Renoprotective mechanisms by these
agents are due to restricting renal angiotensin activity,
lowering intraglomerular pressure, and reducing
oxidative stress [32,33]. In our study, number of
patients administered ACE inhibitors is not different
between probucol group and non-probucol group.
Furthermore, in subjects administered ACE inhibitor,
increase of urinary protein was significantly higher in
non-probucol group than probucol group (Table 4).
From these findings, it is indicated that ACE inhibitors
did not influence on the present data as a bias, and
probucol might have additional renoprotective effect.
We consider that the same effect might be expected in
the case of combination therapy of probucol and ARB.