Ethnopharmacological relevance: Antidesma bunius Spreng. (Phyllantaceae), Averrhoa bilimbi L. (Oxalidaceae),
Biophytum sensitivum (L.) DC. (Oxalidaceae), Ceriops tagal (Perr.) C.B. Rob. (Rhizophoraceae),
Kyllinga monocephala Rottb. (Cyperaceae), and Rhizophora mucronata Lam. (Rhizophoraceae) are used as
remedies to control diabetes. In the present study, these plants were screened for their potential
a-glucosidase inhibitory activity.
Materials and methods: The 80% aqueous ethanolic extracts were screened for their
a-glucosidase
enzyme inhibitory activity using yeast alpha glucosidase enzyme.
Results: Except for A. bilimbi with IC
at 519.8673.07, all manifested a significant enzyme inhibitory
activity. R. mucronata manifested the highest activity with IC
50
50
at 0.0871.82 mgmL
, followed by C.
tagal with IC
50
at 0.8571.46 mgmL
1
and B. sensitivum with IC
50
at 2.2471.58 mgmL
.
Conclusion: This is the first report on the
a-glucosidase inhibitory effect of the six Philippine plants;
thus, partly defining the mechanism on why these medicinal plants possess antidiabetic properties.
1
1
Ethnopharmacological relevance: Antidesma bunius Spreng. (Phyllantaceae), Averrhoa bilimbi L. (Oxalidaceae),Biophytum sensitivum (L.) DC. (Oxalidaceae), Ceriops tagal (Perr.) C.B. Rob. (Rhizophoraceae),Kyllinga monocephala Rottb. (Cyperaceae), and Rhizophora mucronata Lam. (Rhizophoraceae) are used asremedies to control diabetes. In the present study, these plants were screened for their potentiala-glucosidase inhibitory activity.Materials and methods: The 80% aqueous ethanolic extracts were screened for theira-glucosidaseenzyme inhibitory activity using yeast alpha glucosidase enzyme.Results: Except for A. bilimbi with ICat 519.8673.07, all manifested a significant enzyme inhibitoryactivity. R. mucronata manifested the highest activity with IC5050at 0.0871.82 mgmL, followed by C.tagal with IC50at 0.8571.46 mgmL1and B. sensitivum with IC50at 2.2471.58 mgmL.Conclusion: This is the first report on thea-glucosidase inhibitory effect of the six Philippine plants;thus, partly defining the mechanism on why these medicinal plants possess antidiabetic properties.11
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