tThis work presents experimental results on the synthesis of soybean oil-based polymers through emul-sion polymerization process. It was shown that polymeric materials can be successfully synthesized withhigh monomers conversion close to 100% and very high stability, displaying relatively high shelf-life time.Polymeric nanoparticles showing narrow particle size distribution, with average diameter around 80 nm(PdI = 0.213), determined via dynamic light scattering measurements were obtained. It was also observedby calorimetric analysis, that the final polymeric material presents two exothermic transitions and twoglass transition temperatures. This complex thermal behavior probably takes place due to the nature ofthe monomeric mixture (AFFAM—acrylated linolenic, linoleic, and oleic acids in combination with methylmethacrylate), indicating that the final polymer presents a complex macromolecular arrangement. Theglass transition temperature of the polymer lattices was reduced because of the AFFAM incorporationinto the growing polymer chains, and additionally the thermal stability was improved. Regarding theaverage molar masses, it was observed that AFFAM comonomer plays an important role, leading to adecreasing in the mass-average molar mass when the AFFAM concentration is increased in the reactionmedium. Depending on the AFFAM amount, the mass-average molar masses were found within the rangefrom 70,000 g mol−1to 890,000 g mol−1with molar-mass dispersity lying in the interval from 1.7 to 2.4.