2. Burden of Clostridium difficile infection in
immunocompromised patients
2.1. Epidemiology
Immunocompromised patients constitute a high-risk population
for CDI [20e23]. Their increased susceptibility to CDI is
multifactorial and includes generic accepted risk factors for CDI
such as frequent requirements for antibiotic therapy, prolonged
hospitalization and antacid treatment, and common occurrence of
hypoalbuminemia, all known risk factors for CDI [24e26]. Within
defined immunocompromised patient groups, increasing degrees
of immunosuppression are associated with a greater risk for CDI