It can be summarized that it might be difficult to find a nanoparticulate delivery system for which so many regulatorily accepted excipients (lipids, surfactants and stabilizers) are available than for the lipid nanoparticles.
In addition a priori they are made from materials which are natural compounds in the body or are composed of glycerides being made from natural compounds in the body (fatty acids and glycerol).
On top they are easily degraded by processes available in the body.
In addition the dermal administration route further reduces the risks of cytotoxicity or systemic toxicity.
The excellent tolerability of the lipid nanoparticles is supported by many available cosmetic dermal products already being
introduced to the market fulfilling the regulatory requirements towards tolerability and nanotoxicity.
Fromthis it appears justified to call the lipid nanoparticles a “nanosave” carrier.