SUMMARY: Urine is the body fluid most commonly used for biological screening and, as the major route for fluoride (F) excretion is via the kidney, human exposure to F is best measured with the urinary F level. The objectives of the present study were to measure thepH and the levels of albumin, F, and creatininein spot urine samplesfrom 265 healthy Thai students in thelow-FOm Koi district, Chiang Mai province. A histogram of urinary F concentrations was made and the results analysed by the Pearson correlation and a multiple linear regression model. The histogram of the urinary F concentrations was highly skewed toward low values with a mean and standard deviation of 0.8±0.5 mg F/L, a median of 0.7 mg F/L, and an interval or range of 0.2–3.5 mg F/L.A moderately strong correlation was present between urinary F excretion and the urinary F/creatinine ratio (r=0.507, p<0.001). The age, weight, height, body mass index, urinary albumin/creatinine ratio, and urinary F/creatinine ratio were significantly related to the urinary F with a low coefficient of determination (r2=0.324, p<0.001). The results show the urineFlevel and the urinary F/creatinine ratio for normal Thai students in a low-F area and the values found will be useful as guidelines for assessing individuals at risk for excessive occupational or environmental exposure to F.
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