All reactions disappeared at 72-hr
observations. In human we found that our 0.5% Caesalpenia cream either with or without Aloe vera extract was safe as only 2
subjects reported slight itching on their skin sites applied with the herbal cream without Aloe vera extract. No rash was observed
on any formulation. Since the cream with Aloe vera extract exhibited a somewhat lower irritancy than did the one without Aloe
vera, the 0.5% Caesalpenia cream with Aloe vera extract may have a potential for further development for cosmetic products.