During the backward deletion from the full model, CLcr and
amiodarone remained in the model that caused significant
the minimum value of the objective function increase. Therefore, the final model was
as follows: CL/F (L/h) = (1.21 + 0.0532 × CLcr [mL/min]) ×
(1 + 0.787 × AMD), where AMD = 0 for concomitant
administration of amiodarone or 1 otherwise