) with evidence of heterogeneity by subsite (Pheterogeneity=0.05; Pheterogeneity=0.02 for mutagenic activity and B[a]P, respectively). Analyses of advanced and/or multiple adenoma also revealed a positive association for well or very well-done meat (OR=1.45, 95% CI=1.01–2.09), but there was no variation by adenoma type for the other cooking variables or meat mutagens (data not shown).