Sapienza University of Rome was founded in 1303 with the Papal bull In supremae praeminentia dignitatis issued on 20 April 1303 by Pope Boniface VIII, as a Studium for ecclesiastical studies more under his control than the universities of Bologna and Padua,[14] making it the first pontifical university.
In 1431 Pope Eugene IV completely reorganized the studium with the bull In supremae, in which he granted masters and students alike the broadest possible privileges and decreed that the university should include the four schools of Law, Medicine, Philosophy and Theology. He introduced a new tax on wine in order to raise funds for the university; the money was used to buy a palace which later housed the Sant'Ivo alla Sapienza church.
However, the University's days of splendour came to an end during the sack of Rome in 1527, when the studium was closed and the professors dispersed; some were killed. Pope Paul III restored the university shortly after his ascension to the pontificate in 1534.
In the 1650s the university became known as Sapienza, meaning wisdom, a title it retains. In 1703, Pope Clement XI purchased some land with his private funds on the Janiculum, where he made a botanical garden, which soon became the most celebrated in Europe through the labours of the Trionfetti brothers.
University students were newly animated during the 19th-century Italian revival. In 1870, La Sapienza stopped being the papal university and became the university of the capital of Italy. In 1935 the new university campus, planned by Marcello Piacentini, was completed.