Agents that influence oxygen binding
•● 2,3-bisphosphoglycerate (2,3-BPG) only binds to deoxyHb
• (β-chains) → deoxyHb is thus stabilized
•● H+ ions (lower pH) – binding of H+ by Hb lowers its affinity for O2 → Bohr effect
•● CO2 – high CO2 levels in the plasma also result in a right shift of saturation curve = Bohr effect