Cholinesterase inhibitors
Post-mortem studies indicated the reduced choline uptake,
acetylcholine (ACh) release and progressive loss of
cholinergic neurons in AD brain. This “cholinergic deficient
hypothesis” claims that the symptoms of AD is
caused by decreased acetylcholine in the presynapse, thus
increasing acetylcholine by inhibiting its degradation
should improve the memory and cognition impairment in
AD. Since 1993, the FDA approved four cholinesterase