Cancer metabolism has recently become a hotspot
in the field of cancer research [17]. Recent research has
demonstrated that cancer cells often bear a metabolism
characteristic distancing from that of normal cells [18].
This metabolic rewiring in cancer cells involves aberrantly
activated aerobic glycolysis and enhanced de novo lipid
biosynthesis that was driven by metabolism related
enzymes or genes [19]. In this view, to find drugs targeting
the key enzymes or genes involved in cancer cell specific
metabolic pathways may have the potential to disrupt
tumor cell proliferation and survival without affecting
normal cells, thus providing a powerful new intervention
to treat cancer.
Elevated de novo lipogenesis is one of the most