The causality association between ZIKV infection in the first trimester of pregnancy and development of microcephaly or other congenital anomalies has been formally established [29,30]. Most reported cases in the literature are for women who gave birth to new borns with microcephaly and reported symptoms of contracting ZIKV (mostly rash) in their first or second trimester of pregnancy[31–33]. Recently, four fetuses with microcephaly were born in Columbia to women who did not report symptoms of contracting ZIKV, but had a lab evidence of ZIKV infection [34]. A recent reportde scribed ophthalmic findings as macular pigment mottling and loss of foveal reflex associated with microcephaly and intracerebral calcifications in newborn infants whose mothers showed clinical manifestations matching the criteria for ZIKV diagnosis [35]. Inaddition, RNA particles of ZIKV were detected in amniotic fluid analysis of two women with radiological evidence of microcephaly. This finding suggests that the virus crossed the placenta and can be in criminated in producing congenital anomalies [36].