Age-related macular degeneration (AMD) is the age-related disease characterized by chronic
and progressive degeneration of photoreceptors. The retinoprotective effect of lutein complex
(LC) derived from marigold (lutein) and wolfberry (zeaxanthin) was assessed in subjects with
early stage AMD (n = 56). Each subject was instructed to take 60 mL of LC beverage for 5
months. Supplementation with LC substantially escalated the concentrations of serum lutein
and zeaxanthin as well as the activities of antioxidant enzymes and the levels of total
antioxidative capacity, ocular comfort index (OCI) and macular pigment optical density (MPOD)
as compared to baseline. Oxidative stress index (total free radicals and TBARS), inflammatory
markers, best-corrected visual acuity (BCVA), and interocular pressure (IOP) were
concomitantly lowered in subjects when treated with LC for 5 months. Thus, long-term consumption
of LC may suppress the oxidative stress by enhancing the antioxidant status and
thereby preclude the incidence of AMD.