We concluded from the present study that VAD showed
a potent inhibitory effect on XOD in a non-competitive
mode, and its inhibitory activity could be stronger than that
of allopurinol. It is of great interest that the XOD-inhibitory
effect of VAD could be equal to that of a clinically used
drug. In this sense, the dietary use of HWE from Lagerstroemia
speciosa leaves may provide some choices for prevention
and/or treatment of hyperuricemia. However, at this
juncture we have no definite information that the HWE of
Lagerstroemia speciosa leaves possesses the hypouricemic
activity at the in vivo stage. Further studies must elucidate
the hypouricemic effect of HWE from the Lagerstroemia
speciosa leaves as well as its active components in vivo.