The strain is closely related to one that has been circulating in North American birds since 2002. But unlike the bird strain, it has adapted to living in mammals.
It has also evolved mutations known to ease transmission and cause more severe symptoms. Specifically, the virus has the ability to target proteins known as cytokines found in human lungs.
Dr Anne Moscona, from Weill Cornell Medical College in New York City, who led the researchers, said: 'There is a concern that we have a new mammalian-transmissible virus to which humans haven't been exposed yet. It's a combination we haven't seen in disease before.'
The warning is published in the online journal of the American Society for Microbiology, mBio.
One cause for concern was the fact that few scientists had considered the possibility of a bird flu virus infecting seals, said the researchers. It highlighted the fact that pandemic influenza can appear in unexpected ways.
'Flu could emerge from anywhere and our readiness has to be much better than we previously realised,' said Dr Moscona.
'We need to be very nimble in our ability to identify and understand the potential risks posed by new viruses emerging from unexpected sources.
'It's important to realise that viruses can emerge through routes that we haven't considered. We need to be alert to those risks and ready to act on them.'