There is no standard method of treating Jamaican vomiting sickness. Care has been focused on relieving symptoms and providing supportive care. The traditional way of treating a bout of vomiting would always be to replenish the lost fluids in order to achieve an electrolyte, glucose and pH balance. However, here the mainstay of treatment would be to maintain a normal blood glucose level. It is advisable to administer a bolus of hypertonic dextrose solution followed by an infusion of 10% dextrose solution.
Activated charcoal is usually administered if the patient presents within 4 hours of ingestion. If mental status is altered, consideration should be given to airway protection prior to charcoal use.
Vomiting must be taken care of with antiemetics. Seizures could be managed with benzodiazepines [7]. Some patients may require intubation and ventilator support as well.
The administration of riboflavin and glycine has also been reported to antagonize the effects of hypoglycinA intoxication. It is believed that riboflavin stimulates the de novo synthesis of acyl-CoA dehydrogenases while glycine conjugates with excess dicarboxylic acids produced due to impaired lipid metabolism.