The fruit rind of Garcinia mangostana Linn. has been traditionally used for treatment of skin infection, wounds,
dysentery, and diarrhea. -Mangostin, a major constituent of the fruit rind, was reported to possess a strong inhibitory effect
against Propionibacterium acnes and Staphylococcus epidermidis, which is involved in acne development. This study was
conducted to quantitative analyze the content of -mangostin in the fruit rind of this plant collected from 13 locations in the
South and East of Thailand by validated TLC-densitometric method. Antibacterial activity against P. acnes and S. epidermidis
of the extracts was also determined. -Mangostin contents in the fruit rinds and in the 95 % ethanolic extracts were found in
the ranges of 3.39-5.68 and 11.83-23.11 % dry weight, respectively. The samples from the South showed higher contents of
-mangostin (average 17.64 % w/w in the extract and 4.85 % w/w in the dried powder) than the eastern samples. The MIC
values of all extracts against P. acnes and S. epidermidis were in the range of 7.81-15.63 and 15.63-31.25 g/mL, respectively,
while the MBC values were in the range of 15.63-31.25 and 62.50-125.00 g/mL, respectively. The antibacterial activity
and mangostin
content of the samples from different locations were significantly different (p