Precautions:
Paracetamol + Codeine should be used with caution in patients with:
•impaired hepatic function
•impaired renal function
•decreased respiratory reserve e.g. asthma or chronic obstructive pulmonary disease (COPD)
•pre-existing respiratory depression
•raised intracranial pressure or head injury
•prostatic hypertrophy
•hypotension
•hypothyroidism
It should also be used with caution in patients who:
•have a history of drug abuse
•are taking other respiratory depressants or sedatives, including alcohol
•have had recent gastrointestinal tract surgery
Codeine may obscure the diagnosis or the course of gastrointestinal diseases. Prolonged use of codeine may produce physical and psychological dependence.