This study characterized the detection and expression of SP-A
in human sinusmucosa. SP-A is significantly increased in CRS
and decreased in PAR and appears to be expressed by
respiratory epithelial cells and submucosal glandular elements
of the sinonasal mucosa. Further characterization of
this specialized protein is warranted considering the potentialtherapeutic applications of surfactant in the enhancement
of mucociliary clearance.