3.5. Effect of mulberry on MAPK expression
Figs. 3 and 4show the effects of ME on the expression of the MAPK
family in liver and brain samples, respectively, from SAM mice. In
comparison to Group I, Group II showed significantly (Pb.05) greater expression of phosphorylated p38 and JNK in the liver, and decreased
phosphorylated p38 and JNK expression was noted in mice that were
fed with ME. Furthermore, significantly (Pb.05) higher expression
levels of phosphorylated ERK1/2 were also noted in the liver and
brain in SAMP8 mice treated with the high-dose ME. These results
suggest that supplementation with ME might influence signal
transduction pathways by down-regulation of p38 and JNK in the
liver and by up-regulation of ERK1/2 both in the brain and liver