White spot lesions have been prevented over the years using topical fluorides in the form of varnishes, dentifrices, and sealants. They reduce the number and size of white spot lesions. In orthodontics, continuous fluoride release has been developed with fluoridereleasing elastomeric chains, glass ionomer cement, and composites for long treatment periods. Many other methods, including antimicrobial and antibiotic therapies, have been tried, but their efficiency lasts only as long as they are supplied at regular intervals. These disadvantages have caused probiotics to be considered an efficient alternative that could be available in regular dietary supplements without causing major side effects.