Objective: Synovitis is evident in a substantial subpopulation of patients with osteoarthritis (OA) and is
associated with development of pathophysiology. Recently we have shown that adipose-derived stem
cells (ASC) inhibit joint destruction in collagenase-induced experimental OA (CIOA). In the current study
we explored the role of synovitis and alarmins S100A8/A9 in the immunomodulatory capacity of ASCs in
experimental OA.