In rats, water consumption was decreased 21% for males and 23% for females at the highest dose from weeks 53-104. No decreases were reported in food consumption and survival rates were similar for all groups of animals (treated and controls). At interim sacrifices (14 and 66 weeks) no significant differences in body weight, organ weights or body-to-organ weight ratios were reported. No differences were reported in blood chemistry or gross or microscopic histologic parameters. In the second year of the study, body weights were slightly reduced; however, the reduction in body weights was