All patients enrolled in TREAT had diabetes mellitus, renal dysfunction, and anemia; however, patients with retinopathy had more microvascular complications of diabetes (figure 1). Patients with retinopathy also had higher rates of foot ulcers and amputation, all of which occurred at an earlier age compared to those without retinopathy. Among patients with retinopathy, those with a history of laser photocoagulation were significantly more likely to report diabetic neuropathy at baseline than those with less severe retinopathy (64.4% vs 58.6%, p