The series normally follows the antics of Tom in his pursuit of Jerry. However episodes can follow one of four different themes. They are:
Tom and Jerry's antics in a traditional sense.
Tom and Jerry being pets to two witches named Beatie and Hildie.
Tom and Jerry working together by operating an agency called "The Cat and Mouse Detectives," complete with a narrator.
Jerry living in a lab with a rat companion named Napoleon, and Tom being an alley cat.