More experiments with selective antagonists of different dopamine receptors are needed to elucidate the mechanism of action of the BV and melittin, but it is important to note that melittin displayed action on the apomorphine-induced stereotypies without side effects on motor performance or catalepsy with the dose tested. Neither BV nor melittin promoted depressant effect as assessed by the forced swimming test. It has been well demonstrated that drugs with antidepressant activity reduce the time during the animals remained immobile (Borsini and Meli, 1988). Thus, the results indicate a neuroleptic-like but not antidepressant effect for BV.