In conclusion, in vivo micro-CT is a useful tool for the in vivo followup
of bone mass and structure in mice. However, proper optimization
of the scan parameters and study set-up is necessary, as high radiation
doses can alter bone morphological parameters. We here provide
two study set-ups for the in vivo follow-up of both young and old
mice over a study period of 4 weeks without significant side effects of
in vivo X-ray exposure.