Diabetes already affects 415 million people worldwide. In the UK, there will be 5M people with type 2 diabetes (T2D) by 2025, accounting for 1 in 30 prescriptions and £25 billion in annual NHS costs. The establishment of the Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM) builds on existing strength in this area. OCDEM is committed to training the next generation of basic and clinical scientists in the fields of Diabetes, Endocrinology & Metabolism. Several of the OCDEM PIs have joint affiliations with the neighbouring Wellcome Trust Centre for Human Genetics. DPhil Projects in this area are available through the RDM Scholars Programme, the NDM Prize Studentships and the Wellcome Trust funded structured programme on Genomic Medicine and Statistics. Its projects cut across conventional disciplines to include aspects of human statistical and molecular genetics, translational genomics, molecular and cellular biology, islet physiology, integrated physiology and clinical trials. The Department of Physiology, Anatomy and Genetics and the Nuffield Department of Primary Care Health Sciences also have a number of groups doing research in diabetes and metabolism. The Structured DPhil programme in Ion Channels and Disease includes projects on the molecular mechanisms underlying diabetes.