Attachement of the virus to host receptors mediates endocytosis of the virus into the host cell.
The capsid undergoes a conformational change and releases VP4 that opens a pore in the host endosomal membrane and the viral genomic RNA penetrates into the host cell cytoplasm.
VPg is removed from the viral RNA, which is then translated into a processed polyprotein.
In entero-, rhino-, and aphthoviruses, shutoff of cellular cap-dependent translation through the cleavage of translation initiation factors by viral protease.
Replication occurs in viral factories made of membrane vesicles derived from the ER. A dsRNA genome is synthesized from the genomic ssRNA(+).
The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
New genomic RNA is believed to be packaged into preassembled procapsids.
Cell lysis and virus release.
Maturation of provirions by an unknown host protease.