- with regard to the improvement of anticancer treatments modal-ity: as clustered damage sites produced by IR are difficult torepair, this reduced repairability is exploitable in radiotherapythroughout innovative strategies: one interesting approach is toenhance radiosensitivity of cancer cells by targeting the repairpathways of radiation-induced clustered damage and complexDSB through inhibition of specific proteins that are not requiredin the repair pathways for endogenous damage