The Controlled Rosuvastatin Multinational Trial in Heart Failure
(CORONA) and the Effect of Rosuvastatin in Patients with Chronic
Heart Failure Trial (GISSI-HF) both assessed whether rosuvastatin
(compared with placebo) improved cardiovascular endpoints and
mortality in patients with heart failure who were not already taking
statins.15,16 CORONA included participants with systolic heart
failure of ischaemic aetiology only, whereas GISSI-HF included participants
with all causes and types of heart failure. For each trial, the
addition of rosuvastatin 10 mg once daily to background pharmacotherapy
did not significantly reduce incident CVD or all-cause
mortality. However, in light of the substantial number of study
participants in CORONA and GISSI-HF experiencing death from
arrhythmic causes, worsening heart failure, or non-cardiovascular
causes, and the relatively low number of myocardial infarctions
(MIs), the ability to detect a statistically significant benefit for statins
preventing MI and stroke may have been limited.
The Controlled Rosuvastatin Multinational Trial in Heart Failure(CORONA) and the Effect of Rosuvastatin in Patients with ChronicHeart Failure Trial (GISSI-HF) both assessed whether rosuvastatin(compared with placebo) improved cardiovascular endpoints andmortality in patients with heart failure who were not already takingstatins.15,16 CORONA included participants with systolic heartfailure of ischaemic aetiology only, whereas GISSI-HF included participantswith all causes and types of heart failure. For each trial, theaddition of rosuvastatin 10 mg once daily to background pharmacotherapydid not significantly reduce incident CVD or all-causemortality. However, in light of the substantial number of studyparticipants in CORONA and GISSI-HF experiencing death fromarrhythmic causes, worsening heart failure, or non-cardiovascularcauses, and the relatively low number of myocardial infarctions(MIs), the ability to detect a statistically significant benefit for statinspreventing MI and stroke may have been limited.
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