Canine demodicosis is a dermatologic disease that occurs when mites colonize the hair follicles and sebaceous glands [1]. Demodex canis was the main causative agent of canine demodicosis and it is characterized by the presence of large numbers of Demodex mites. The three recognized canine Demodex mites are Demodex canis, Demodex injai, and Demodex cornei [2–4]. Scabies is a transmissible and zoonotic ectoparasitic skin infection caused by tiny mites of the species Sarcoptes scabiei. It is transmitted readily among the animals, often even throughout an entire household, by skin to skin contact. The parasite commonly affects young dogs and dogs with poor nutrition but can affect healthy dogs that are exposed to the mites [5]. Literatures related to the individual types of mange mites in different animals were available from the last decade. There are no reports about the mixed infection of Demodex and Sarcoptes in dogs. This paper reports the rare occurrence of mixed demodectic and sarcoptic mange in dogs and their therapy.