Report on Carcinogens, Thirteenth Edition
National Toxicology Program, Department of Health and Human Services
For Table of Contents, see home page:
http://ntp.niehs.nih.gov/go/roc13
1,3-Butadiene
CAS No. 106-99-0
Known to be a human carcinogen
First listed in the
Fifth Annual Report on Carcinogens
(1989)
H
2
C
C
H
H
C
CH
2
Carcinogenicity
1,3-Butadiene is
known to be a human carcinogen
based on sufficient
evidence of carcinogenicity from studies in humans, including epide
-
miological and mechanistic studies. 1,3
-
Butadiene was first listed in
the
Fifth Annual Report on Carcinogens
in 1989 as
reasonably antic
-
ipated to be a human carcinogen
based on sufficient evidence of car
-
cinogenicity from studies in experimental animals. The listing was
revised to
known to be a human carcinogen
in the
Ninth Report on
Carcinogens
in 2000.