Hot-start PCR is a form of PCR that focuses on the maximization of product yield. To reach this goal, chemical modifications are used to limit polymerase activity prior to the reaction. This limitation reduces non-specific polymerase amplification. Next, the reaction, itself, is performed at extremely high temperatures using polymerase obtained from thermophilic organisms, such as Achaea bacteria from ocean vents. These elevated temperatures further prevent non-specific polymerase amplification, resulting in a larger yield of the target product.