However, the validated in vitro methods focus on distinguishing corrosive and more irritant chemicals from non-irritants, and they do not make categorisation possible, in contrast to the in vivo method. In the dossiers submitted to the SCCS, nearly all the studies were performed on albino rabbits; only a few used in vitro methods. The majority of the in vivo studies performed on rabbits followed the OECD guidelines, which were adopted in 1981 and updated successively in 1987, 2002 and then recently in 2012 (OECD, 2012).